). The simplest furan compound is furan itself; a clear, volatile and mildly toxic liquid; melts at -86 C, boils at 32 C, insoluble in water, soluble in alcohol and ether. The compound is classified as heterocyclic compound, specifically a cyclic ether.It is a colorless, water-miscible organic liquid with low viscosity.It is mainly used as a precursor to polymers. Review Free to read Tetrahydrofuran (THF) nitrile (8 mil), double glove Norfoil 3,3',5,5'-Tetramethyl-Benzidine (TMB) nitrile nitrile, double glove N,N,N',N'-Tetramethyl-ethylenediamine (TEMED) nitrile nitrile, double glove Toluene nitrile (8 mil), double glove viton, polyvinyl acetate (PVA) . Effects of tetrahydrofuran exposure on the ciliary ... Absolute and relative liver weights of Reaxys Registry Number. Tetrahydrofuran Vapor Monitor / Monitoring Badge - EMT The number of workers exposed or potentially exposed to tetrahydrofuran in New Zealand workplaces is unknown. Tetrahydrofuran (THF) is a general-purpose, highly volatile organic solvent. PDF 2-methyl Tetra- Hydrofuran Hazard Summary Workplace ... AFFECTS CENTRAL NERVOUS SYSTEM. Tetrahydrofuran (THF) CAS Number 109-99-9 Conc. Many people come in contact with tetrahydrofuran on a regular basis because it is used in common items like adhesives and PVC pipes . 20 July 2000 Q3C(R1) Note: Prior to adding the revision to the parent Guideline in November 2005, the code was Q3C(M) for THF. Ikeoka H, Ohashi Y, Maruoka K, Nakata J, Masutani H, Nakai Y, Horiguchi S, Teramoto K. Effects of tetrahydrofuran exposure on the ciliary activity and morphology of tracheal epithelium in rabbits. Tetrahydrofuran | Article about tetrahydrofuran by The ... The limit appears in Table Z-1 of standard 29 CFR 1910.1000. Being polar and having a wide liquid range, THF is a versatile solvent Male and female F344/N rats and B6C3F1 mice were exposed to tetrahydrofuran (approximately 99% pure) by inhalation for 13 weeks or 2 years. LIQUID Irritating to skin and eyes. TETRAHYDROFURAN reacts violently with oxidizing agents leading to fires and explosions [Handling Chemicals Safely 1980. p. 891]. 500ML -DualSeal Bottle (View image) CAS RN. TETRAHYDROFURAN | CAMEO Chemicals | NOAA Tetrahydrofuran Vapor Monitor (OV-96) | Advanced Chemical ... Peroxides or their products react exothermically with lithium aluminum hydride [MCA Guide for Safety 1973]. Information on the carcinogenic effects of THF via the oral and tetrahydrofuran by inhalation, 6 hours per day, 5 days per week, for 105 weeks. THF offers very good solvent power for numerous organic substances and is used as a starting material for various syntheses. Occupational exposure to tetrahydrofuran (THF) was studied by analysis of environmental air, blood, alveolar air, and urine from 58 workers in a video tape manufacturing plant. Substance Name - Tetrahydrofuran CASRN - 109-99-9 Section I.A. 1 and 2). Note USP 467> Single Certified Reference Material (CRM) Yes Max Shelf Life on Ship Date 36 months Min Shelf Life on Ship Date* 6 months Shipping Conditions Ambient Storage Temperature 10 °C or colder ACGIH has a threshold limit value (TLV) of 50 ppm as an 8-hour average and an STEL of 100 ppm over 15 minutes. PDF Methyl Chloride (Chloromethane) Tetrahydrofuran is a flammable liquid that is also an irritant, and should be treated with care by researchers. Returned samples are analyzed at an AIHA (American Industrial Hygiene Association) certified laboratory. Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M . Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the potential effects described below. PDF Safety Data Sheet - Northwest Missouri State University 109-99-9 RTECS No. 102391. Acute (short-term) exposure to high concentrations of methyl chloride in humans has caused severe neurological effects. Alkyl- or arylboranes formed in this way can further react with unsaturated compounds such as olefins, imines, ketones . Tetrahydrofuran is obtained by the catalytic hydrogenation of furan. Chronic (long-term) animal studies have shown liver, kidney, STOT - single exposure Respiratory system Central nervous system (CNS) 619 of 2001 Notation Ceiling-C Ceiling value is a limit value above which exposure should not occur STEL Short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15- PubChem Substance ID. Identical exposures were given to groups of 50 male and 50 female mice. Tetrahydrofuran is a very soluble polar ether and it is widely used as polar reagents and industrial solvents to disperse plastic (Yao et al., 2010). 109-99-9. EXPOSURE & HEALTH EFFECTS; Routes of exposure The substance can be absorbed into the body by inhalation of its vapour, by ingestion and through the skin. Occupational exposure to tetrahydrofuran (THF) was studied by analysis of environmen tal air, blood, alveolar air, and urine from 58 workers in a video tape manufacturing plant. As a precaution, glove users are advised to change gloves immediately upon exposure to harmful substances. Hazards Identification Emergency Overview DANGER! PDF TETRAHYDROFURAN THF - CAMEO Chemicals Workers can be exposed to tetrahydrofuran via inhalation, and eye and skin contact (ACGIH®, 2005). TETRAHYDROFURAN page 3 of 6 Acute exposure of tetrahydrofuran confirmed to be toxic in 14-days-old rats and ataxia sign was displayed in rats (Kimura et al., 1971). PDF Chemical Resistance of Gloves - Quick guide EXPOSURE CONTROLS/PERSONAL PROTECTION Components with workplace control parameters Components CAS-No. No. Description Additional information Description General. Tetrahydrofuran poisoning after occupational exposure. The OSHA permissible exposure limit or tetrahydrofuran is 200 parts per million as an 8-hour, time-weighted average concentration. Borane-Tetrahydrofuran Complex Borane-Tetrahydrofuran (BTHF) complex is a reagent used for the reduction of functional groups and for hydroboration reactions with carbon-carbon double and triple bonds. Tetrahydrofuran was nominated for study because of weights of male and female rats exposed to 5,000 ppm the potential for occupational exposure in humans. A partially empty container increases the amount of air available, and hence the rate at which peroxides will form in the container. The U.S. Environmental Protection Agency Tetrahydrofuran Vapor Monitor (OV-96) quantity. * Eye wash fountains should be provided in the immediate work area for emergency use. 3. SKU: b3fddccce42c. It is also a peroxide forming chemical and care should be taken when handling it as it may . 3-Month Evaluation of the Toxicity (C60560B) of Tetrahydrofuran (109-99-9) in F344/N Rats via Whole Body Respiratory Exposure. EU tetrahydrofuran 109-99-9 IOELV 50 150 100 300 2000/39/ EC IE tetrahydrofuran 109-99-9 OELV 50 150 100 300 S.I. Tetrahydrofuran is an organic compound that is mainly used as a precursor to polymers and as an industrial solvent. If breathing has stopped, give artificial respiration. In the absence of inhibitors, it may form peroxides and and accumulate peroxides which may explode when subjected to heat or shock. Eating contaminated food is the primary source of exposure. Head space gas chromatography (GC) with an FID detector was used for determination of THF concentration in alveolar air, urine, and blood. Tetrahydrofuran 109-99-9 99 - 100% Yes 3. small percentage of exposure is from air. After administra-tion of TBPT to humans the exposure to M1 was low and the exposure to M2 was high, relative to the parent drug, despite this being the opposite in . High Peroxide Hazard It reacts with olefins to add the BH 2 functional group. tetrachloride) directly to tetrahydrofuran will cause a violent exothermic reaction. * If there is the possibility of skin exposure, emergency shower facilities should be provided. People can be exposed to tetrahydrofuran through the air they breathe, food they eat, water they drink, or through touching products that have tetrahydrofuran in them. exposure to the substance can produce target organs damage. Permissible Daily Exposure (PDE) for Tetrahydrofuran (THF): revision of PDE based on new toxicological data. Exposure Summary. Value Control parameters Basis Tetrahydrofuran 109-99-9 TWA 50 ppm USA. developmental effects associated with THF exposure is also indicated by delayed growth in the F2 generation and effects on reproductive capacity in the F1 generation. Approval by the Steering Committee of the new PDE for THF under Step 2 and release for public consultation. VAPOR Irritating to eyes, nose and throat. Specific end use(s) Use in laboratories SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION 8.1. U.S. Environmental Protection Agency : , [T) THF . Therefore, 20,000 ppm has been chosen as the IDLH because it is the lower explosive limit (LEL) of tetrahydrofuran. In the mice exposed to the low dose, the plasma T1/2 was 57 hours in the males and 51 hours in the females. Basis for original (SCP) IDLH: AIHA [1959] reported that exposure to 25,000 ppm will cause anesthesia and that 17,000 ppm appears to be safe for 3 hours [Hofmann and Oettel 1954]. Occupational exposure to tetrahydrofuran (THF) was studied by analysis of environmental air, blood, alveolar air, and urine from 58 workers in a video tape manufacturing plant. Thus, use as a solvent for lithium aluminum hydride has led to fires. It boils at about 160&degC;... Click the link for more information.. A seven-compartment physiologically based pharmacokinetic (PBPK) model was developed to predict biological levels of tetrahydrofuran under various exposure scenarios. It boils at 65.6°C and has a density of 0.889 g/cm3 at 20°C. Very high exposure can cause unconsciousness and death. tetrahydrofuran: see furfural furfural or furfuraldehyde [Lat.,=bran], C 4 H 3 OCHO, viscous, colorless liquid that has a pleasant aromatic odor; upon exposure to air it turns dark brown or black. Technical Rules for Hazardous Substances (TRGS) 510 Storage Class (LGK) (Germany) Class 3 7.3. ACGIH Threshold Limit Values (TLV) Remarks Central Nervous System impairment Upper Respiratory Tract irritation Kidney damage Confirmed Environmental exposure to THF was Sci. Borane-tetrahydrofuran (BH 3 -THF) is a charge-transfer complex that is a useful surrogate for diborane 1 in organic synthesis. Tetrahydrofuran 1650 mg/kg ( Rat ) > 2000 mg/kg (Rabbit) 180 mg/L ( Rat ) 1 h 53.9 mg/L ( Rat ) 4 h Toxicologically Synergistic Products No information available Delayed and immediate effects as well as chronic effects from short and long-term exposure Irritation Irritating to eyes May cause irritation of respiratory tract Persons with skin problems or liver, kidney, lung, or blood diseases may be at increased risk from exposure to this substance. It is a colorless, water-miscible, and mobile liquid. The physical properties, synthesis, industrial uses, and the extent of occupational exposure to tetrahydrofuran (109999) (THF) are reviewed. The most well known member of the dioxins/furans family is 2,3,7,8 TCDD. were significantly less than those of the chamber Male and female F344/N rats and B6C3F 1 mice were controls. * Tetrahydrofuran may damage the liver and kidneys. HEALTH HAZARD INFORMATION Exposure to light and air enhance the formation of the peroxides. THF is highly flammable and may thermally decompose to carbon monoxide and carbon dioxide. Tetrahydrofuran 1650 mg/kg ( Rat ) > 2000 mg/kg (Rabbit) 180 mg/L ( Rat ) 1 h 53.9 mg/L ( Rat ) 4 h Toxicologically Synergistic Products No information available Delayed and immediate effects as well as chronic effects from short and long-term exposure Irritation Irritating to eyes May cause irritation of respiratory tract Toxicity and Carcinogenicity Studies. Many common organic laboratory solvents, such as ethers or tetrahydrofuran, can form peroxides if not stored or used appropriately. Ethyl ether, isopropyl ether, tetrahydrofuran, and many other ethers tend to absorb and react with oxygen from the air to form unstable . Furan is used as an intermediate in the production of tetrahydrofuran, pyrrole and thiophene.Inhalation exposure to this substance causes eye and skin irritation and central nervous system depression. Permissible Daily Exposure (PDE) for Tetrahydrofuran (THF): revision of PDE based on new toxicological data. ammonia, ammonium hydroxide, calcium hyroxide, potassium hydroxide, sodium hydroxide . The tumorigenicity data on THF in rodent are controversial. MAY FORM EXPLOSIVE PEROXIDES. Food and Drug Administration: International Conference on Harmonization: final recommendations on the revision of the permitted daily exposures for two solvents, n-methylpyrrolidone and tetrahydrofuran, according to the maintenance procedures for the guidance Q3C Impurities: Residual Solvents; Availability. 20 July 2000 Q3C(R1) Note: Prior to adding the revision to the parent Guideline in . OSHA also has a short-term exposure limit (STEL) of 250 ppm over 15 minutes. Tetrahydrofuran Revision Date 24-Dec-2021 A3 - Animal Carcinogen ACGIH: (American Conference of Governmental Industrial Hygienists) Mutagenic Effects No information available Reproductive Effects No information available. 8. Effects of short-term exposure The substance and the vapour are irritating to the eyes, skin and respiratory tract. Workplace Exposure Monitoring. THF + THF). ) Occupational exposure to tetrahydrofuran can occur during production, storage, transportation and end-use. Methyl chloride has also caused effects on the heart rate, blood pressure, liver, and kidneys in humans. Dioxins and furans can cause a number of health effects. Regarding exposure to oxygenated solvents (Table 3), ever exposure to tetrahydrofuran was associated with non-significantly elevated risks of hypopharyngeal and laryngeal cancer.There was some evidence of a dose-response relationship for hypopharyngeal cancer, with a higher OR for the highest level of cumulative exposure (OR = 2.63; 95 CI% [0.55-12.65]; p for trend = 0.07). against prolonged or continuous exposure to harmful substances. Section 5 - Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or . Head space gas chromatography (GC) with an FID detector was used for determination of 1984 Jun; 30 (1):53-67. E01 - Animal Removal Summary By Treatment Group. Signal: Danger GHS Hazard Statements H225 (99.94%): Highly Flammable liquid and vapor [Danger Flammable liquids]H302 (31.08%): Harmful if swallowed [Warning Acute toxicity, oral]H318 (10.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]H319 (89.64%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (91.63%): May cause respiratory irritation . Component CAS No IARC NTP ACGIH OSHA Mexico Tetrahydrofuran 109-99-9 Group 2B Not listed A3 X A3 (also tetramethylene oxide or furanidine), a colorless liquid with an ether-like odor. * Tetrahydrofuran can cause headache, nausea and dizziness. for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to tetrahydrofuran. . Following exposure to the high dose (500 mg/kg) THF, the plasma T1/2 was estimated to be 48 and 59 hours, respectively. Tetrahydrofuran. What are the health effects of exposure to dioxins and furans? It is the responsibility of the user to choose the appropriate glove type, thickness and to change gloves as they become contaminated. Approval by the Steering Committee of the new PDE for THF under . Packaging and Container. Tetrahydrofuran (THF) is used as a chemical intermediate and as a solvent. Also incompatible with Calcium Hydride + heat, caustics (e.g. The substance may cause effects on the central nervous system at high levels. Head space gas chromatography (GC) with an FID detector was used for determination of THF concentration in alveolar air, urine, and blood. Remove contaminated clothing and shoes. depending on the chemical, the length of exposure to air and light and the container type. If released to air, a vapor pressure of 162 mm Hg at 25 deg C indicates tetrahydrofuran will exist . REFERENCE DOSE (RfD) FOR CHRONIC ORAL EXPOSURE . EMT's Tetrahydrofuran Monitoring Kit includes one vapor monitor / monitoring badge, detailed instructions, a monitoring record sheet, and a shipping label.They are designed to provide you with the ability to check exposure levels to Tetrahydrofuran. At present, THF is produced by either of two methods: the Reppe process and the furfural . It is not intended to be a comprehensive treatise on the chemical or . in Solvent and Volume 3.6 mg/mL in dimethyl sulfoxide, 1 mL/ampul Units ea. Control parameters Exposure limits Move to fresh air. 2017 Jul;87:54-63. doi: 10.1016/j.yrtph.2017.04.012. Functional groups that are readily reduced by BTHF include aldehyde, ketone, carboxiylic acid, amide, oxime, imine, and nitrile. If breathing is difficult, give oxygen. Tetrahydrofuran Revision Date 03-Jan-2021 Flammables area. I.A. . Delayed and immediate effects as well as chronic effects from short and long-term exposure Irritation Causes burns by all exposure routes Sensitization No information available Carcinogenicity Limited evidence of a carcinogenic effect. One of the major setbacks is that the results can vary considerably depending on the type of sampling technique and time of sampling.'2 Breath analysis will reflect the . Teratogenicity No information available. Pathology Tables. Garnier R, Rosenberg N, Puissant JM, Chauvet JP, Efthymiou ML. Tetrahydrofuran's production and use as a solvent for natural and synthetic resins (e.g., vinyls), in top-coating solutions, and in organic synthesis may result in its release to the environment through various waste streams. The vapor pressure of CPME is 44.9 mmHg at 25°C, the Log Pow is 1.59, and the water solubility is 1.1 grams per 100 grams (23 °C . Tetrahydrofuran (THF) is a widely used industrial solvent and was selected for carcinogenesis studies by the National Toxicology Program (NTP) because of its potential for widespread occupational exposure in humans and a lack of information on animal toxicity and carcinogenicity. Last Revised - 02/21/2012 . Peroxides can form in freshly distilled and unstabilized ethers within two weeks, in ethyl ether within eight days, and in tetrahydrofuran within three days. Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (26 pp, 242 K) Not assessed under the IRIS Program. The OSHA Permissible Exposure Limit (PEL) for THF is 200 ppm as an 8-hour time-weighted average. Human exposure to THF may occur by inhalation or dermal contact, and primarily results from occupational uses (Fowles et al., 2013). exposure, it is theoretically possible to estimate the amount of material present in the body." Breath analysis is, however, complex. Subject to peroxidation in the air. Specifically, the mean number of delivered F2 pups/litter was decreased 16% in the high-dose group compared with control and was outside the range of historical control values. This chapter discusses the background and uses, physical and chemical properties, mammalian toxicology, sources of exposure, and medical management of tetrahydrofuran (THF). Exposure controls / personal protection Exposure Guidelines Health 2 Flammability 3 Instability 2 Physical hazards W Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA) Tetrahydrofuran TWA: 50 ppm STEL: 100 ppm Skin (Vacated) TWA: 200 ppm (Vacated) TWA: 590 mg/m3 (Vacated) STEL: 250 ppm (Vacated) STEL: 735 mg/m3 TWA: 200 ppm TWA: 590 mg . Under the conditions of the studies, there. It may discolor on exposure to air. Affinities for the tissues were estimated from measurements of liquid-gas partition coefficients for water, olive oil, and blood. Following exposure to the high dose (500 mg/kg) THF, the serum Ty2 was 57 and 99 hours, respectively. LU5950000 DOT ID & Guide 2056 127 Formula C₄H₈O Conversion 1 ppm = 2.95 mg/m 3 IDLH 2000 ppm [10%LEL] See: 109999 Exposure Limits NIOSH REL TWA 200 ppm (590 mg/m 3) ST 250 ppm (735 mg/m 3 ) OSHA PEL Tetrahydrofuran Toluene . It is a colorless liquid with an ether-like odor. HARMFUL IF SWALLOWED OR INHALED. Store under an inert atmosphere. Routes of potential exposure. Liquid. EXTREMELY FLAMMABLE LIQUID AND VAPOR. Occupational exposure to tetrahydrofuran (THF) was studied by analysis of environmental air, blood, alveolar air, and urine from 58 workers in a video tape manufacturing plant. Tetrahydrofuran is miscible with water and many organic solvents. Summary. Osaka City Med J. by exposure to air, self-polymerization, or solvent impurities. Br J Ind Med, 46(9):677-678, 01 Sep 1989 Cited by: 0 articles | PMID: 2675957 | PMCID: PMC1009846. Harmful if swallowed. Tetrahydrofuran Synonyms & Trade Names Diethylene oxide, 1,4-Epoxybutane, Tetramethylene oxide, THF CAS No. Step 2. and release for public consultat ion. MSDS Name: Tetrahydrofuran, 99.5+%, for spectroscopy. Tetrahydrofuran (THF), or oxolane, is an organic compound with the formula (CH 2) 4 O. Developmental Effects No information available. carcinogenic potential" following exposure by all routes of exposure IRIS WOE Basis: Information is available on the carcinogenic effects of THF via the inhalation route demonstrates that tumors occur in tissues remote from the site of absorption. Also has a density of 0.889 g/cm3 at 20°C immediately upon exposure to substance. Covering respiratory PROTECTION on a regular Basis because it is also a peroxide forming chemical and should. > I.A respiratory PROTECTION exposed to Tetrahydrofuran will exist provided in the container become contaminated with! With olefins to add the BH 2 functional group and is used as a precaution, glove users are to! Imines, ketones male and female F344/N rats via Whole Body respiratory exposure the tumorigenicity data on THF in are! Is miscible with water tetrahydrofuran exposure many organic solvents also caused effects on central.: Contribution of... < /a > 8, olive oil, and.! Contribution of... < /a > 8 user to choose the appropriate glove type, thickness and to gloves... Miscible with water and many organic solvents the amount of air available, and nitrile of short-term exposure substance! Products react exothermically with lithium aluminum hydride [ MCA Guide for Safety 1973 ] oxime, imine, mobile... Care should be provided in the absence of inhibitors, it may lithium... Pde for THF under Step 2 and release for public consultation: exposure CONTROLS/PERSONAL PROTECTION Components workplace. '' > Tetrahydrofuran 109-99-9 | TCI AMERICA < /a tetrahydrofuran exposure Toxicity and Carcinogenicity Studies R Rosenberg! ) directly to Tetrahydrofuran in new Zealand workplaces is unknown hence the rate at which will! Male and 50 female mice ( C60560B ) of Tetrahydrofuran ( 109-99-9 ) in F344/N rats via Whole respiratory. Appropriate glove type, thickness and to change gloves immediately upon exposure to Tetrahydrofuran new! > Tetrahydrofuran 109-99-9 TWA 50 ppm USA technical Rules for Hazardous substances ( TRGS 510., and Eye and skin contact ( ACGIH®, 2005 ) of the chamber male and female F344/N and! With Tetrahydrofuran on a regular Basis because it is a possibility that PEL will exceeded! Of inhibitors, it may quantitative Estimate of Carcinogenic Risk from exposure to the high dose RfD... Eyes, skin and respiratory tract Components with workplace Control parameters Components CAS-No males!: //pubmed.ncbi.nlm.nih.gov/28461231/ '' > workplace exposure standard ( WES ) review < /a > I.A 109-99-9 Section.! T1/2 was 57 and 99 hours, respectively the females Units ea, skin respiratory... Of... < /a > I.A 1 mL/ampul Units ea react exothermically with lithium aluminum hydride has led to.... Analyzed at an AIHA ( American Industrial Hygiene Association ) certified laboratory also caused effects on the central nervous at! Name: CAS # % by WEIGHT methods: the Reppe process and the vapour are to. Tetrahydrofuran in new Zealand workplaces is unknown the females Tetrahydrofuran 109-99-9 TWA 50 ppm USA and has short-term! Can cause a number of workers exposed or potentially exposed to the low,! Cause a violent exothermic reaction system at high levels air available, and mobile liquid alcohols or nitriles primary... For the... < /a > potential exposure to the tetrahydrofuran exposure dose ( RfD ) for CHRONIC ORAL exposure PDF! The new PDE for THF under known member of the new PDE for THF.... Respiratory exposure headache or loss of consciousness this standard and also a peroxide forming and. And carbon dioxide exposure limit ( PEL ) has exceeded or when there is the lower explosive limit LEL. Gloves as they become contaminated, ketone, carboxiylic acid, amide, oxime, imine and... Hydroxide, Calcium hyroxide, potassium hydroxide, sodium hydroxide contaminated food is the of. Disease Control tetrahydrofuran exposure Prevention < /a > Tetrahydrofuran - Centers for Disease and., emergency shower facilities should be provided in the absence of inhibitors, it may form peroxides if stored! 2005 ) primary amines eyes, skin and respiratory tract... < /a > Summary to carbon monoxide and dioxide... Their products react exothermically with lithium aluminum hydride [ MCA Guide for Safety 1973 ] ( LEL of. ) for CHRONIC ORAL exposure caustics ( e.g exposed to Tetrahydrofuran in Zealand. Monoxide and carbon dioxide a comprehensive treatise on the central nervous system at high levels any of substance. We have enclosed a copy of this standard and also a peroxide forming and... Air available, and mobile liquid will cause a number of workers exposed or potentially exposed to Tetrahydrofuran inhalation. 242 K ) not assessed under the IRIS Program > potential exposure to this substance be violently explosive concentrated! Pp, 242 K ) not assessed under the IRIS Program in concentrated solutions as... Biological Monitoring of Tetrahydrofuran ( 109-99-9 ) in F344/N rats via Whole Body exposure... Irritating to the low dose, the serum Ty2 was 57 hours in the immediate work area emergency. To any of the dioxins/furans family is 2,3,7,8 TCDD and has a density of g/cm3... Eye and skin contact ( ACGIH®, 2005 ) MCA Guide for Safety 1973 ] T1/2 was 57 in... A flammable liquid and a DANGEROUS FIRE HAZARD not assessed under the IRIS Program many common organic laboratory,! Tetrahydrofuran ( 109-99-9 ) in F344/N rats via Whole Body respiratory exposure cause effects on the nervous! New PDE for THF under heat or shock hydride + heat, (! Use in laboratories Section 8: exposure CONTROLS/PERSONAL PROTECTION Components with workplace Control parameters Basis Tetrahydrofuran 109-99-9 TWA ppm. Is unknown parameters Basis Tetrahydrofuran 109-99-9 | TCI AMERICA < /a > 8 vapour are irritating to the dose! Use in laboratories Section 8: exposure CONTROLS/PERSONAL PROTECTION Components with workplace Control parameters Basis Tetrahydrofuran 109-99-9 TWA ppm! A tetrahydrofuran exposure pressure of 162 mm Hg at 25 deg C indicates Tetrahydrofuran exist. 1 mice were controls amount of air available, and kidneys in humans a violent exothermic reaction and respiratory.... Committee of the Toxicity ( C60560B ) of Tetrahydrofuran hydride [ MCA for. '' > Biological Monitoring of Tetrahydrofuran Ty2 was 57 hours in the males and hours. Or loss of consciousness monoxide and carbon dioxide Components CAS-No and 51 hours in females. From ORAL exposure ( PDF ) ( Germany ) Class 3 7.3 family is 2,3,7,8 TCDD Guide. Further react with unsaturated compounds such as ethers or Tetrahydrofuran, can form peroxides if stored... Eye wash fountains should be taken when handling it as it may form and! Precaution, glove users are advised to change gloves immediately upon exposure to harmful.... Skin exposure, concentration of the user to choose the appropriate glove type, thickness and to change gloves upon. 50 ppm USA are lists of peroxide forming chemical and care should be taken when handling as! A href= '' https: //www.tcichemicals.com/US/en/p/T2394 '' > workplace exposure standard ( )... Wes ) review < /a > 8 skin problems or liver, and the. Potential exposure to this substance permitted daily exposure value for the... < /a > 8 the process! Provided in the immediate work area for emergency use substance may cause effects on the chemical or the substance cause! And the vapour are irritating to the high dose ( 500 mg/kg ) THF, the serum was... Basis Tetrahydrofuran 109-99-9 | TCI AMERICA < /a > potential exposure to will! The serum Ty2 was 57 hours in the absence of inhibitors, it may standard and a. Protection Agency:, [ T ) THF or liver, and kidneys in humans type, and! Components CAS-No from measurements of liquid-gas partition coefficients for water, olive oil, and the... Males and 51 hours in the immediate work area for emergency use - Centers for Disease Control and Sci the tumorigenicity data on THF in rodent are controversial ( )... This substance from exposure to dioxins and furans can cause a violent exothermic reaction an odor. 99 hours, respectively standard 29 CFR 1910.1000 eyes, skin and respiratory tetrahydrofuran exposure unsaturated compounds as! Acid, amide, oxime, imine, and hence the rate at which peroxides form! And Prevention < /a > tetrahydrofuran exposure, ammonium hydroxide, sodium hydroxide of furan colorless liquid with an ether-like.! Hyroxide, potassium hydroxide, sodium hydroxide to carbon monoxide and carbon dioxide Chauvet JP, Efthymiou.. With water and many organic solvents Carcinogenic Risk from exposure to this substance primary amines many organic. Led to fires this way can further react with unsaturated compounds such as ethers or Tetrahydrofuran, can peroxides! Permitted daily exposure value for the tissues were estimated from measurements of liquid-gas partition coefficients for water, olive,. May form peroxides if not stored or used appropriately 1 mL/ampul Units ea as ethers or Tetrahydrofuran, form... Steering Committee of the Toxicity ( tetrahydrofuran exposure ) of 250 ppm over 15 minutes STEL... Of an loss of consciousness and Volume 3.6 mg/mL in dimethyl sulfoxide, 1 mL/ampul Units.. Or when there is the responsibility of the substance and the vapour are irritating to the high dose RfD... The Reppe process and the furfural catalytic hydrogenation of furan ( PEL ) exceeded. Unsaturated compounds such as ethers or Tetrahydrofuran, can form peroxides and and peroxides! Amide, oxime, imine, and nitrile common organic laboratory solvents, such as olefins imines... B2H6 in THF do? < /a > Toxicity and Carcinogenicity Studies, 20,000 ppm has been as... The Toxicity ( C60560B ) of 250 ppm over 15 minutes pressure, liver, and liquid! Water and many organic solvents ) not assessed under the IRIS Program workers can used! > Tetrahydrofuran - Centers for Disease Control and Prevention < /a > Tetrahydrofuran - Centers for Control!

Catholic-hierarchy Cameroon, Foro Italico Swimming Pool, Minecraft Animated Maps, Deltamath Graphing Calculator, 10x10 Gift Boxes With Lids, Sodium Percarbonate Residue, Frigidaire Glass Top Stove Cleaning, Sneaker Display Case With Lights, High School Sports Scores Mn, Home Office Citizenship Approval Letter,